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Atovaquone/proguanil

This medication (trade name Malarone™) is a combination of two medications in one tablet. It has been the second line anti-malarial used in the ADF since 2006. It is used when doxycycline is either not tolerated or is not suitable.

Malarone needs to be taken daily starting at least two days before deployment to a malarious area and continuing for one week after leaving the area.

Malarone is generally very well tolerated; however it does have some unwanted side effects. It can cause gastrointestinal upset (usually when using treatment doses rather than the lower doses used for prevention of malaria) and other side effects may include skin rash, fatigue, fever and liver problems. Neuropsychological symptoms, such as sleeping problems, vivid dreams, dizziness or hallucinations, are uncommon but can occur in rare cases.

More information:

Consumer medicines information about Malarone is available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2010-CMI-04713-3

Product information for prescribers is also available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2010-PI-04712-3

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